Characteristic

Placebo (n = 15)

Transdermal rivastigmine (n = 15)

Mean age (range), y

56 (50 - 65)

56 (51 - 61)

Male, n (%)

10 (67)

9 (60)

Race, n (%)

White Black Hispanic

6 (40) 3 (20) 6 (40)

1 (7) 11 (73) 3 (20)

Mean BMI (range)

28 (26 - 30)

28 (26 - 30)

Cirrhosis etiology, n (%)

Alcohol Hepatitis B Hepatitis C Nonalcoholic steatohepatitis Other

6 (40) 1 (7) 5 (33) 2 (13) 1 (7)

2 (13) 3 (20) 7 (47) 1 (7) 2 (13)

HE grade, n (%)

2 3

9 6

8 7

Mean MELD score (range)

20 (18 - 22)

20 (18 - 22)

Serum ammonia, mol/L^a

239

245^b

Mean MES

14

14

Mean ORT time, s^c

122

125

Mean TT time, s^d

158

161

EEG, n (%)

Normal Grade 1 Grade 2 Grade 3

9 (60) 3 (20) 2 (13) 1 (7)

10 (67) 2 (13) 3 (20) 0 (0)